My journey has been a little different. I have not had Prednisone. After I was diagnosed I was immediately started on mestinon and it was very effective immediately. I started on a low dose 15mg twice a day with additional doses as needed. Then I learned the importance of knowing my triggers. Like too much exercise, shopping in stores with lots of fluorescent lights looking from side to side while walking down the isles, Infections, certain antibiotics, certain vaccinations and who knows what else. Many of these triggers I experienced back to back during a short period of time while also getting COVID and mestinon stopped working for me. My neurologist got me approved for IVIG and that treatment brought me back to a place where mestinon was working again. I am taking much higher dose of it though 60mg 3 x a day. My understanding of Prednisone is it needs to be ramped up slowly and may take a while to work.