Cazzie has it nailed here, except that she left out diabetes. The side effects of prednisone are terrible. The goal should be to reduce the dosage, over time, as far as possible without falling off the MG cliff. It took me two years to get down to 5 MG daily, relying on azathioprine to keep me stable. I don't see any short-term side effects at that level. There is new research that found a 3.6 MG daily dose was essentially safe. That is to say, it resulted in no observable bad effects out to seven years, the limit of the study. The side-effect curve starts there and goes up sharply as the dosage increases.