I'm trying it right now, so we'll see. Huperzine works just like pyridostigmine. It is an acetylcholinesterase inhibiter, which means it suppresses the mechanism that removes acetylcholine, leaving more available for use by your muscles. The difference is that Huperzine penetrates the blood/brain barrier and increases the acetylcholine levels in your brain as well That might potentially relieve brain fog and some mental decline. I met one user a few days ago who takes it in conjunction with pyridostigmine. There are many small clinical studies. I read more than 40. But there is unlikely to ever be a major medical study because it is an OTC supplement.