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VYVGART: Has Your IgG (Immunoglobulin G) Gotten Dangerously Low?

Jodi Enders

Have you been treated with VYVGART for your Myasthenia gravis, and have your IgG (Immunoglobulin G) gotten dangerously low? Did your doctor have you continue with the treatment or alter your dose?

From the Vyvgart manufacturer's website: "VYVGART is specifically designed to attach to and block the neonatal Fc receptor (FcRn), resulting in the reduction of IgG antibodies, including the harmful AChR antibodies that cause gMG symptoms" (https://vyvgart.com/content/brand-site-patient-global/language-masters/en/about-vyvgart/how-vyvgart-works.html).

"Normal: IgG
Age IgG (mg/dL)
0-1 year: 136-890
1-4 years: 443-1243
4-10 years: 566-1359
10-19 years: 684-1581
>19 years 650-1600"
(https://www.uncmedicalcenter.org/mclendon-clinical-laboratories/available-tests/immunoglobulin-g-igg/).

"Reductions in total IgG levels in adolescents or adults may be classified as mild-moderate (300–600 mg/dL), significant (100–299 mg/dL), or profoundly reduced (<100 mg/dL)" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3099256/#:~:text=Reductions%20in%20total%20IgG%20levels,%3C100%20mg%2FdL).).

https://myasthenia-gravis.com/news/efgartigimod-fda-approval